Glaucomas represent a heterogeneous group of eye disorders characterized by irreversible damage of the optic nerve and usually elevated intraocular pressure, leading to vision loss and ultimately, if untreated, to blindness. Genetic factors are considered to play a key role in all major forms of glaucoma. Clinically and etiologically congenital glaucomas are differentiated from glaucoma manifesting in early or late adulthood. Finally, pseudoexfoliation glaucoma is a common form of secondary glaucoma manifesting at an advanced age. Research projects at the institute deal with all forms aiming mainly at the identification of the underlying genetic defects and mechanisms.